About the CaPP3 Study

About the CaPP3 Study

Click here to find out whether you are eligible for CaPP3.

The Cancer Prevention Project 3 (CaPP3) will focus first on finding the right dose of aspirin for people with a mismatch repair gene defect, the underlying cause of Lynch syndrome.  Three thousand people who have Lynch syndrome will be invited to take part in a dose non-inferiority trial. On joining the study the recruits will be asked to provide a blood sample before receiving a supply of enteric coated aspirin tablets.  The recruits will take three tablets each day for two years. One will be a dummy tablet and at least one will contain aspirin.  We will keep a secret code so that no-one will know whether they are taking 100mg, 300mg or 600mg of aspirin per day.  The blood samples will help us to investigate whether some people react differently to aspirin and also whether we can predict, using blood markers, who will develop cancers in the future.  Anyone who takes part in CaPP3 will be invited to be part of a national registry which can provide careful follow-up to report side effects and provide detailed information about any cancers or polyps which are found on routine checkups.

The CaPP3 study will be recruited through the UK Regional Genetics Centres. International centres including Finland, Denmark, Germany, Sweden, Israel and Australia are hoping to secure funding to be involved in the study. 

People who started in the CAPP2 study can be involved in the CaPP3 study.  

Further information on the study can be obtained from the Study Team

 

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Latest News

  • 09

    Jun

    2015

    New Sites Open to Recruitment

    posted on Tuesday, 9th June 2015
    New Sites Open to Recruitment

    Glasgow are now open to recruitment.  Please contact the Genetics Team in Glasgow if you are interested in taking part.

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  • 16

    Feb

    2015

    St Mark's recruit to CaPP3

    posted on Monday, 16th February 2015
    St Mark's recruit to CaPP3

    Good news! The first CaPP3 participant outside of Newcastle was recruited by the Genetics team at St Mark's Hospital, London North West on 11th February 2015.

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